Vermin is a rat/human hybrid that has fought Spider-Man.
When Spider-Man went into the sewer he fought and defeated the Lizard. Only seconds later Spider-Man was confronted by a human/rat hybrid called Vermin. Spider-Man then fought Vermin and was easily able to defet him.
Vermin was granted superhuman abilities like those of a rat through genetic engineering. His powers are proportional to those of a human sized rat.
In the comics
Very little is known about Edward Whelan except that he was homeless and living on the streets of New York City.
At some point, he was picked up off the streets Baron Helmut Zemo and Arnim Zola and subjected to a process that bestowed upon him various ratlike traits and attributes. Able to command rats and other wild beasts Edward, who was now called Vermin, as dispatched by Zemo and Zola to stalk and kill their long-time enemy Captain America.
After randomly slashing a cab driver to attract attention Vermin encountered Captain American a rundown are of Harlem, and despite unleashing a pack of rats against the Avengers, Vermin was overpowered. Captain America took Vermin to S.H.I.E.L.D. headquarters for questioning, but Vermin somehow managed to escape shortly afterwards. He then met with Zemo and Zola, who took him to Zemo's headquarters in Mexico.
When Zemo had captured Captain America himself, he decided Vermin's usefulness to him was over. He then shackled Vermin next to Captain America in a dungeon and set loose two of his more powerful mutates upon them. Vermin killed one of the mutates and escaped the chamber. He stole aboard Zemo's escape craft, and when Zemo fled from the castle sometime later, Vermin attacked Zemo viciously, wounding him.
Returning to New York City, Vermin once again prowled the city streets, finally going on a rampage during the San Gennaro Festival in the Little Italy section of Manhattan. He was apprehended by Captain America and Spider-Man and turned him over to local authorities.